Risking thromboembolism: podoplanin and glioma

Thromboembolism in patients with high-grade glioma.

OBJECTIVE To identify factors related to increased or decreased risk of thromboembolism (TE) in patients with high-grade glioma. DESIGN We performed a retrospective analysis of 64 patients enrolled in two prospective clinical trials of chemotherapy and radiation therapy for newly diagnosed high-grade glioma. MATERIAL AND METHODS The 64 patients were 18 years of age or older and had histolog...

Venous Thromboembolism in Patients with High-Grade Glioma.

Venous thromboembolism (VTE), incorporating both deep vein thrombosis and pulmonary embolism, is a common, morbid, and potentially fatal condition. Patients undergoing surgery are at increased risk of VTE due to many perioperative factors, and patients undergoing surgery for high-grade glioma (HGG) have been found to be at an even higher risk than general surgical patients. Chemical prophylaxis...

Risking Death to Give Life

Risking Peace: Contesting Foreign Policy

This paper explores the causes of domestic conflict over foreign policy in the context of a dynamic learning model. One state is composed of two political parties that are uncertain about how another state will respond to cooperative and confrontational policies. To resolve this uncertainty, they must implement policies and update on the basis of the observed outcome. While both parties have in...

Podoplanin discovery, structure and expression regulation 3. Podoplanin and lymphatic vessel development 4. Podoplanin and tumor metastasis facilitated by thrombus formation 5. Podoplanin and cancer cell migration, invasion and progression 6. Podoplanin expression in cells of normal and cancerous stroma

Cancer-associated fibroblasts (CAFs) are well-known to be part of the tumor microenvironment. This heterogeneous population of cells of the tumor microenvironment via secretion of various growth factors and cytokines was shown to contribute to increased cancer cell proliferation rate, migration, invasiveness and other key processes such as angiogenesis and lymphangiogenesis. Recent studies iden...